Cargando…

Strong and Specific Recognition of CAG/CTG Repeat DNA (5’‐dWGCWGCW‐3’) by a Cyclic Pyrrole‐Imidazole Polyamide

Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole‐imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequence. The double‐stranded DNA melting temperatur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hirose, Yuki, Ohno, Tomo, Asamitsu, Sefan, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298716/ https://www.ncbi.nlm.nih.gov/pubmed/34796607 http://dx.doi.org/10.1002/cbic.202100533

Ejemplares similares

A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models
por: Ikenoshita, Susumu, et al.
Publicado: (2023)

Tandem trimer pyrrole–imidazole polyamide probes targeting 18 base pairs in human telomere sequences
por: Kawamoto, Yusuke, et al.
Publicado: (2015)

Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants
por: Han, Yong-Woon, et al.
Publicado: (2012)

Telomere Visualization in Tissue Sections using Pyrrole–Imidazole Polyamide Probes
por: Sasaki, Asuka, et al.
Publicado: (2016)

Pyrrole-imidazole hairpin polyamides with high affinity at 5′–CGCG–3′ DNA sequence; influence of cytosine methylation on binding
por: Minoshima, Masafumi, et al.
Publicado: (2008)

Novel Auger-Electron-Emitting (191)Pt-Labeled Pyrrole–Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma
por: Obata, Honoka, et al.
Publicado: (2023)

Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs
por: Ide, Satoru, et al.
Publicado: (2021)

Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates
por: Hargrove, Amanda E., et al.
Publicado: (2012)

Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
por: Asamitsu, Sefan, et al.
Publicado: (2019)

Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing
por: Chandran, Anandhakumar, et al.
Publicado: (2016)

Photocontrolled DNA minor groove interactions of imidazole/pyrrole polyamides
por: Müller, Sabrina, et al.
Publicado: (2020)

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice
por: Synold, Timothy W., et al.
Publicado: (2012)

Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit
por: Yang, Fei, et al.
Publicado: (2013)

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
por: Hargrove, Amanda E., et al.
Publicado: (2015)

Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide
por: Diaz-Perez, Silvia, et al.
Publicado: (2018)

The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding
por: Lin, Jason, et al.
Publicado: (2020)

Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model
por: Igarashi, Jun, et al.
Publicado: (2015)

Inhibition of DNA Methylation at the MLH1 Promoter Region Using Pyrrole–Imidazole Polyamide
por: Shinohara, Ken-ichi, et al.
Publicado: (2016)

Submolecular dissection reveals strong and specific binding of polyamide–pyridostatin conjugates to human telomere interface
por: Mandal, Shankar, et al.
Publicado: (2019)

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome
por: Lin, Jason, et al.
Publicado: (2016)

CAG·CTG repeat instability in cultured human astrocytes
por: Farrell, Brian T., et al.
Publicado: (2006)

Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides
por: Buchmueller, Karen L., et al.
Publicado: (2005)

Efficient Synthesis of Peptide and Protein Functionalized Pyrrole-Imidazole Polyamides Using Native Chemical Ligation
por: Janssen, Brian M. G., et al.
Publicado: (2015)

Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide
por: Alagarswamy, Kokiladevi, et al.
Publicado: (2018)

RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons
por: Asamitsu, Sefan, et al.
Publicado: (2023)

Quantitation of Pyrrole-Imidazole Polyamide in Rat Plasma by High-Performance Liquid Chromatography Coupled with UV Detection
por: Kamei, Tomonori, et al.
Publicado: (2012)

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer
por: Krishnamurthy, Sakthisri, et al.
Publicado: (2021)

Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides
por: Ota, Yoko, et al.
Publicado: (2021)

Sequence-specific electron injection into DNA from an intermolecular electron donor
por: Morinaga, Hironobu, et al.
Publicado: (2013)

Length-dependent energetics of (CTG)(n) and (CAG)(n) trinucleotide repeats
por: Amrane, Samir, et al.
Publicado: (2005)

Replication dependent instability at (CTG)•(CAG) repeat hairpins in human cells
por: Liu, Guoqi, et al.
Publicado: (2010)

The Role of XPG in Processing (CAG)(n)/(CTG)(n )DNA Hairpins
por: Hou, Caixia, et al.
Publicado: (2011)

Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
por: Liu, Guoqi, et al.
Publicado: (2012)

Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions
por: Barros, Stephanie A., et al.
Publicado: (2015)

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase
por: Cinesi, Cinzia, et al.
Publicado: (2016)

Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models
por: Wheeler, Vanessa C., et al.
Publicado: (2021)

Addressable and unidirectional energy transfer along a DNA three-way junction programmed by pyrrole-imidazole polyamides
por: Su, Wu, et al.
Publicado: (2013)

Identification of a novel E-box binding pyrrole-imidazole polyamide inhibiting MYC-driven cell proliferation
por: Mishra, Rajeev, et al.
Publicado: (2015)

Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells
por: Takagi, Keiko, et al.
Publicado: (2020)

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma
por: Tsujimoto, Akiko, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u7ck0fv6868oe2r8qpm66ma9un