Cargando…
G2019S LRRK2 Mutation Enhances MPP(+)-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons
Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to mimic human diseases of related cell types, but it is unclear whether they can successfully mimic age-related diseases such as Parkinson’s disease (PD). We generated iPSCs lines from three patients with familial PD associat...
Autores principales: | Chen, Ying, Yin, Qing, Cheng, Xiao-Yu, Zhang, Jin-Ru, Jin, Hong, Li, Kai, Mao, Cheng-Jie, Wang, Fen, Bei, Hong-Zhe, Liu, Chun-Feng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298923/ https://www.ncbi.nlm.nih.gov/pubmed/35873822 http://dx.doi.org/10.3389/fnins.2022.947927 |
Ejemplares similares
-
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
por: Borgs, Laurence, et al.
Publicado: (2016) -
In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation
por: Chang, Kuo-Hsuan, et al.
Publicado: (2021) -
Spread of neuronal degeneration in a dopaminergic, Lrrk-G2019S model of Parkinson disease
por: Hindle, Samantha J., et al.
Publicado: (2013) -
Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons
por: Fellgett, Alison, et al.
Publicado: (2021) -
Quercetin Protects against MPP(+)/MPTP-Induced Dopaminergic Neuron Death in Parkinson's Disease by Inhibiting Ferroptosis
por: Lin, Zhi-Hao, et al.
Publicado: (2022)