Borcalein: a Carborane‐Based Analogue of Baicalein with 12‐Lipoxygenase‐Independent Toxicity

12‐Lipoxygenase is crucial for tumour angiogenesis. 5,6,7‐Trihydroxy‐2‐phenyl‐4H‐1‐benzopyran‐4‐one (baicalein) is a suitable inhibitor for this enzyme but is rapidly metabolised in vivo. Thus, an improvement of the metabolic stability is necessary to enhance the therapeutic efficiency. An emerging...

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Detalles Bibliográficos
Autores principales: Kuhnert, Robert, Kuhnert, Lydia, Sárosi, Menyhárt‐B., George, Sven, Draca, Dijana, Paskas, Svetlana, Hofmann, Bettina, Steinhilber, Dieter, Honscha, Walther, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298951/
https://www.ncbi.nlm.nih.gov/pubmed/34694057
http://dx.doi.org/10.1002/cmdc.202100588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298951/
https://www.ncbi.nlm.nih.gov/pubmed/34694057
http://dx.doi.org/10.1002/cmdc.202100588

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