A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages

Current genetic tools designed to target macrophages in vivo often target cells from all myeloid lineages. Therefore, we sought to generate a novel transgenic mouse which has a tamoxifen inducible Cre-recombinase under the control of the human CD68 promoter (hCD68-CreERT2). To test the efficiency an...

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Detalles Bibliográficos
Autores principales: Rumianek, Agata N., Davies, Ben, Channon, Keith M., Greaves, David R., Purvis, Gareth S. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298978/
https://www.ncbi.nlm.nih.gov/pubmed/35874787
http://dx.doi.org/10.3389/fimmu.2022.918636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298978/
https://www.ncbi.nlm.nih.gov/pubmed/35874787
http://dx.doi.org/10.3389/fimmu.2022.918636

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