Carrier Protein‐Free Enzymatic Biaryl Coupling in Arylomycin A2 Assembly and Structure of the Cytochrome P450 AryC

The arylomycin antibiotics are potent inhibitors of bacterial type I signal peptidase. These lipohexapeptides contain a biaryl structural motif reminiscent of glycopeptide antibiotics. We herein describe the functional and structural evaluation of AryC, the cytochrome P450 performing biaryl coupling...

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Detalles Bibliográficos
Autores principales: Aldemir, Hülya, Shu, Shuangjie, Schaefers, Francoise, Hong, Hanna, Richarz, René, Harteis, Sabrina, Einsiedler, Manuel, Milzarek, Tobias M., Schneider, Sabine, Gulder, Tobias A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299028/
https://www.ncbi.nlm.nih.gov/pubmed/34725865
http://dx.doi.org/10.1002/chem.202103389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299028/
https://www.ncbi.nlm.nih.gov/pubmed/34725865
http://dx.doi.org/10.1002/chem.202103389

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