Cargando…
Using fractional polynomials and restricted cubic splines to model non‐proportional hazards or time‐varying covariate effects in the Cox regression model
The Cox proportional hazards model is used extensively in clinical and epidemiological research. A key assumption of this model is that of proportional hazards. A variable satisfies the proportional hazards assumption if the effect of that variable on the hazard function is constant over time. When...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299077/ https://www.ncbi.nlm.nih.gov/pubmed/34806210 http://dx.doi.org/10.1002/sim.9259 |