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Late‐Stage Amination of Drug‐Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium‐Catalyzed C−H Activation

The functionalization of C−H bonds, ubiquitous in drugs and drug‐like molecules, represents an important synthetic strategy with the potential to streamline the drug‐discovery process. Late‐stage aromatic C−N bond–forming reactions are highly desirable, but despite their significance, accessing amin...

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Detalles Bibliográficos
Autores principales: Weis, Erik, Johansson, Magnus J., Martín‐Matute, Belén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299223/
https://www.ncbi.nlm.nih.gov/pubmed/34672032
http://dx.doi.org/10.1002/chem.202103510