Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells

The presence of m(6)A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme.

Detalles Bibliográficos
Autor principal: Nachtergaele, Sigrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299351/
https://www.ncbi.nlm.nih.gov/pubmed/35857761
http://dx.doi.org/10.1371/journal.pbio.3001717
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author Nachtergaele, Sigrid
author_facet Nachtergaele, Sigrid
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description The presence of m(6)A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme.
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spelling pubmed-92993512022-07-21 Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells Nachtergaele, Sigrid PLoS Biol Primer The presence of m(6)A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme. Public Library of Science 2022-07-20 /pmc/articles/PMC9299351/ /pubmed/35857761 http://dx.doi.org/10.1371/journal.pbio.3001717 Text en © 2022 Sigrid Nachtergaele https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Nachtergaele, Sigrid
Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title_full Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title_fullStr Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title_full_unstemmed Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title_short Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
title_sort enzymes flying under the radar: cryptic mettl3 can persist in knockout cells
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299351/
https://www.ncbi.nlm.nih.gov/pubmed/35857761
http://dx.doi.org/10.1371/journal.pbio.3001717
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