Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity

7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it could escape the serious side effects chara...

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Detalles Bibliográficos
Autores principales: Kirsanov, Kirill, Fetisov, Timur, Antoshina, Elena, Trukhanova, Lubov, Gor’kova, Tatiana, Vlasova, Olga, Khitrovo, Irina, Lesovaya, Ekaterina, Kulbachevskaya, Nataliya, Shcherbakova, Tatiana, Belitsky, Gennady, Yakubovskaya, Marianna, Švedas, Vytas, Nilov, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299380/
https://www.ncbi.nlm.nih.gov/pubmed/35873588
http://dx.doi.org/10.3389/fphar.2022.842316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299380/
https://www.ncbi.nlm.nih.gov/pubmed/35873588
http://dx.doi.org/10.3389/fphar.2022.842316

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