Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants

Crizotinib is a small‐molecule, multitargeted tyrosine kinase inhibitor that exhibits decreased aqueous solubility at a higher pH. This open‐label, randomized, phase 1 study (NCT01549574) evaluated the effect of multiple doses of the proton pump inhibitor esomeprazole on the pharmacokinetics (PK) of...

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Detalles Bibliográficos
Autores principales: Xu, Huiping, O'Gorman, Melissa, Matschke, Kyle, Boutros, Tanya, Brega, Nicoletta, Tan, Weiwei, Bello, Akintunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299459/
https://www.ncbi.nlm.nih.gov/pubmed/34825782
http://dx.doi.org/10.1002/cpdd.1032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299459/
https://www.ncbi.nlm.nih.gov/pubmed/34825782
http://dx.doi.org/10.1002/cpdd.1032

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