Noncanonical activation of GLI signaling in SOX2(+) cells drives medulloblastoma relapse

SRY (sex determining region Y)–box 2 (SOX2)–labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms propagating them. Single-cell transcriptomic analyses of the most common malignant pediatric brain tumor, medulloblastoma (MB), revealed the...

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Detalles Bibliográficos
Autores principales: Swiderska-Syn, Marzena, Mir-Pedrol, Júlia, Oles, Alexander, Schleuger, Olga, Salvador, April D., Greiner, Sean M., Seward, Cara, Yang, Fan, Babcock, Benjamin R., Shen, Chen, Wynn, Daniel T., Sanchez-Mejias, Avencia, Gershon, Timothy R., Martin, Vanesa, McCrea, Heather J., Lindsey, Kathryn G., Krieg, Carsten, Rodriguez-Blanco, Jezabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299538/
https://www.ncbi.nlm.nih.gov/pubmed/35857834
http://dx.doi.org/10.1126/sciadv.abj9138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299538/
https://www.ncbi.nlm.nih.gov/pubmed/35857834
http://dx.doi.org/10.1126/sciadv.abj9138

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