Differences in ion-RNA binding modes due to charge density variations explain the stability of RNA in monovalent salts

The stability of RNA increases as the charge density of the alkali metal cations increases. The molecular mechanism for this phenomenon remains elusive. To fill this gap, we performed all-atom molecular dynamics pulling simulations of HIV-1 trans-activation response RNA. We first established that th...

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Detalles Bibliográficos
Autores principales: Henning-Knechtel, Anja, Thirumalai, D., Kirmizialtin, Serdal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299541/
https://www.ncbi.nlm.nih.gov/pubmed/35857829
http://dx.doi.org/10.1126/sciadv.abo1190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299541/
https://www.ncbi.nlm.nih.gov/pubmed/35857829
http://dx.doi.org/10.1126/sciadv.abo1190

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