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Differences in ion-RNA binding modes due to charge density variations explain the stability of RNA in monovalent salts
The stability of RNA increases as the charge density of the alkali metal cations increases. The molecular mechanism for this phenomenon remains elusive. To fill this gap, we performed all-atom molecular dynamics pulling simulations of HIV-1 trans-activation response RNA. We first established that th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299541/ https://www.ncbi.nlm.nih.gov/pubmed/35857829 http://dx.doi.org/10.1126/sciadv.abo1190 |