Cargando…

Microtubule-binding core of the tau protein

The protein tau associates with microtubules to maintain neuronal health. Posttranslational modifications of tau interfere with this binding, leading to tau aggregation in neurodegenerative disorders. Here, we use solid-state nuclear magnetic resonance (NMR) to investigate the structure of the micro...

Descripción completa

Detalles Bibliográficos
Autores principales:	El Mammeri, Nadia, Dregni, Aurelio J., Duan, Pu, Wang, Harrison K., Hong, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299549/ https://www.ncbi.nlm.nih.gov/pubmed/35857846 http://dx.doi.org/10.1126/sciadv.abo4459

Ejemplares similares

Amyloid fibril structures of tau: Conformational plasticity of the second microtubule-binding repeat
por: El Mammeri, Nadia, et al.
Publicado: (2023)

Atomic structure of the open SARS-CoV-2 E viroporin
por: Medeiros-Silva, João, et al.
Publicado: (2023)

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding
por: Solon, April L., et al.
Publicado: (2021)

The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
por: Dorrego-Rivas, Ana, et al.
Publicado: (2022)

Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
por: Dregni, Aurelio J., et al.
Publicado: (2022)

Articular fibrocartilage-targeted therapy by microtubule stabilization
por: Li, Jiawei, et al.
Publicado: (2022)

Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution
por: Akıl, Caner, et al.
Publicado: (2022)

Microtubule-based perception of mechanical conflicts controls plant organ morphogenesis
por: Stöckle, Dorothee, et al.
Publicado: (2022)

Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
por: Tsukita, Kazuto, et al.
Publicado: (2023)

Ubiquitin is a carbon dioxide–binding protein
por: Linthwaite, Victoria L., et al.
Publicado: (2021)

Adenovirus core protein V reinforces the capsid and enhances genome release from disrupted particles
por: Martín-González, Natalia, et al.
Publicado: (2023)

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
por: Mann, Jacob R., et al.
Publicado: (2023)

PAXX binding to the NHEJ machinery explains functional redundancy with XLF
por: Seif-El-Dahan, Murielle, et al.
Publicado: (2023)

CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state–sensitive manner
por: Luo, Wangxi, et al.
Publicado: (2023)

Initial spindle positioning at the oocyte center protects against incorrect kinetochore-microtubule attachment and aneuploidy in mice
por: Kincade, Jessica N., et al.
Publicado: (2023)

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression
por: Chan, Byron, et al.
Publicado: (2023)

RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis
por: Qian, Baomei, et al.
Publicado: (2022)

The SARS-CoV-2 spike protein binds and modulates estrogen receptors
por: Solis, Oscar, et al.
Publicado: (2022)

The structure of a polyketide synthase bimodule core
por: Tittes, Yves U., et al.
Publicado: (2022)

An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation
por: Yang, Xin, et al.
Publicado: (2021)

MagneTEskin—Reconstructing skin by magnetically induced assembly of autologous microtissue cores
por: Fuchs, Christiane, et al.
Publicado: (2021)

RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation
por: Ma, Shengyun, et al.
Publicado: (2023)

Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma
por: Zimmerman, Mark W., et al.
Publicado: (2021)

Membrane-induced tau amyloid fibrils
por: El Mammeri, Nadia, et al.
Publicado: (2023)

Structure of native HIV-1 cores and their interactions with IP6 and CypA
por: Ni, Tao, et al.
Publicado: (2021)

ATP-binding cassette protein ABCF1 couples transcription and genome surveillance in embryonic stem cells through low-complexity domain
por: Choi, Eun-Bee, et al.
Publicado: (2021)

Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles
por: Sarmadi, Morteza, et al.
Publicado: (2022)

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
por: Toelzer, Christine, et al.
Publicado: (2022)

Structures of neurokinin 1 receptor in complex with G(q) and G(s) proteins reveal substance P binding mode and unique activation features
por: Thom, Cristian, et al.
Publicado: (2021)

The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core
por: Mannino, Robert G., et al.
Publicado: (2023)

Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs
por: Wang, Qian, et al.
Publicado: (2022)

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
por: Rennie, Martin L., et al.
Publicado: (2022)

Tracking the ATP-binding response in adenylate kinase in real time
por: Orädd, Fredrik, et al.
Publicado: (2021)

Coupling of protein condensates to ordered lipid domains determines functional membrane organization
por: Wang, Hong-Yin, et al.
Publicado: (2023)

Arf GTPase activates the WAVE regulatory complex through a distinct binding site
por: Yang, Sheng, et al.
Publicado: (2022)

ATG16L1 adopts a dual–binding site mode to interact with WIPI2b in autophagy
por: Gong, Xinyu, et al.
Publicado: (2023)

Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules
por: Teixeira, Simão P. B., et al.
Publicado: (2021)

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization
por: Norris, Michael J., et al.
Publicado: (2022)

Native holdup (nHU) to measure binding affinities from cell extracts
por: Zambo, Boglarka, et al.
Publicado: (2022)

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
por: Olivieri, Cristina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7p2807j8oo8if0dda2u3ednt63