A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines

A new cobalt catalyst is presented for the domino hydroformylation‐reductive amination reaction of olefins. The optimal Co‐tert‐BuPy‐Xantphos catalyst shows good to excellent linear‐to‐branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions...

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Detalles Bibliográficos
Autores principales: Yang, Ji, Delolo, Fábio G., Spannenberg, Anke, Jackstell, Ralf, Beller, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299624/
https://www.ncbi.nlm.nih.gov/pubmed/34738697
http://dx.doi.org/10.1002/anie.202112597
Descripción
Sumario:A new cobalt catalyst is presented for the domino hydroformylation‐reductive amination reaction of olefins. The optimal Co‐tert‐BuPy‐Xantphos catalyst shows good to excellent linear‐to‐branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.

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