A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines

A new cobalt catalyst is presented for the domino hydroformylation‐reductive amination reaction of olefins. The optimal Co‐tert‐BuPy‐Xantphos catalyst shows good to excellent linear‐to‐branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions...

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Detalles Bibliográficos
Autores principales: Yang, Ji, Delolo, Fábio G., Spannenberg, Anke, Jackstell, Ralf, Beller, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299624/
https://www.ncbi.nlm.nih.gov/pubmed/34738697
http://dx.doi.org/10.1002/anie.202112597
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author Yang, Ji
Delolo, Fábio G.
Spannenberg, Anke
Jackstell, Ralf
Beller, Matthias
author_facet Yang, Ji
Delolo, Fábio G.
Spannenberg, Anke
Jackstell, Ralf
Beller, Matthias
author_sort Yang, Ji
collection PubMed
description A new cobalt catalyst is presented for the domino hydroformylation‐reductive amination reaction of olefins. The optimal Co‐tert‐BuPy‐Xantphos catalyst shows good to excellent linear‐to‐branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.
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spelling pubmed-92996242022-07-21 A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines Yang, Ji Delolo, Fábio G. Spannenberg, Anke Jackstell, Ralf Beller, Matthias Angew Chem Int Ed Engl Communications A new cobalt catalyst is presented for the domino hydroformylation‐reductive amination reaction of olefins. The optimal Co‐tert‐BuPy‐Xantphos catalyst shows good to excellent linear‐to‐branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts. John Wiley and Sons Inc. 2021-12-02 2022-01-10 /pmc/articles/PMC9299624/ /pubmed/34738697 http://dx.doi.org/10.1002/anie.202112597 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Yang, Ji
Delolo, Fábio G.
Spannenberg, Anke
Jackstell, Ralf
Beller, Matthias
A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title_full A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title_fullStr A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title_full_unstemmed A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title_short A Selective and General Cobalt‐Catalyzed Hydroaminomethylation of Olefins to Amines
title_sort selective and general cobalt‐catalyzed hydroaminomethylation of olefins to amines
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299624/
https://www.ncbi.nlm.nih.gov/pubmed/34738697
http://dx.doi.org/10.1002/anie.202112597
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