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In vitro recovery of FIX clotting activity as a marker of highly functional hepatocytes in a hemophilia B iPSC model

BACKGROUND AND AIMS: Pluripotent stem cell–derived hepatocytes differentiated in monolayer culture are known to have more fetal than adult hepatocyte characteristics. If numerous studies tend to show that this immature phenotype might not necessarily be an obstacle to their use in transplantation, o...

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Detalles Bibliográficos
Autores principales: Luce, Eléanor, Steichen, Clara, Allouche, Mickaël, Messina, Antonietta, Heslan, Jean‐Marie, Lambert, Thierry, Weber, Anne, Nguyen, Tuan Huy, Christophe, Olivier, Dubart‐Kupperschmitt, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299628/
https://www.ncbi.nlm.nih.gov/pubmed/34687060
http://dx.doi.org/10.1002/hep.32211