Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders

Maytansinol is a valuable precursor for the preparation of maytansine derivatives (known as maytansinoids). Inspired by the intriguing structure of the macrocycle and the success in targeted cancer therapy of the derivatives, we explored the maytansinol acylation reaction. As a result, we were able...

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Detalles Bibliográficos
Autores principales: Marzullo, Paola, Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Álvarez‐Bernad, Beatriz, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl‐Heinz, Prota, Andrea E., Díaz, J. Fernando, Pieraccini, Stefano, Passarella, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299702/
https://www.ncbi.nlm.nih.gov/pubmed/34788896
http://dx.doi.org/10.1002/chem.202103520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299702/
https://www.ncbi.nlm.nih.gov/pubmed/34788896
http://dx.doi.org/10.1002/chem.202103520

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