A Click Chemistry Approach to Targeted DNA Crosslinking with cis‐Platinum(II)‐Modified Triplex‐Forming Oligonucleotides

Limitations of clinical platinum(II) therapeutics include systemic toxicity and inherent resistance. Modern approaches, therefore, seek new ways to deliver active platinum(II) to discrete nucleic acid targets. In the field of antigene therapy, triplex‐forming oligonucleotides (TFOs) have attracted i...

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Detalles Bibliográficos
Autores principales: Hennessy, Joseph, McGorman, Bríonna, Molphy, Zara, Farrell, Nicholas P., Singleton, Daniel, Brown, Tom, Kellett, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299770/
https://www.ncbi.nlm.nih.gov/pubmed/34652881
http://dx.doi.org/10.1002/anie.202110455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299770/
https://www.ncbi.nlm.nih.gov/pubmed/34652881
http://dx.doi.org/10.1002/anie.202110455

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