A Specialized Dehydrogenase Provides l‐Phenyllactate for FR900359 Biosynthesis

d‐Phenyllactate (PLA) is a component of the selective Gq protein inhibitor and nonribosomal cyclic depsipeptide FR900359 (FR). Here we report a detailed biochemical investigation of pla biosynthesis and its incorporation into the natural product FR. The enzyme FrsC, member of the lactate/malate dehy...

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Detalles Bibliográficos
Autores principales: Klöppel, Sophie, Richarz, René, Wirtz, Daniel A., Vasenda, Natalia, König, Gabriele M., Crüsemann, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299796/
https://www.ncbi.nlm.nih.gov/pubmed/34846772
http://dx.doi.org/10.1002/cbic.202100569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299796/
https://www.ncbi.nlm.nih.gov/pubmed/34846772
http://dx.doi.org/10.1002/cbic.202100569

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