The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation to better cope. The ISR has also been implicated in cancers, but redundancies in the stress-sensing kinases that trigger the ISR have posed hurdles to dis...

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Detalles Bibliográficos
Autores principales: Hurwitz, Brian, Guzzi, Nicola, Gola, Anita, Fiore, Vincent F, Sendoel, Ataman, Nikolova, Maria, Barrows, Douglas, Carroll, Thomas S, Pasolli, H Amalia, Fuchs, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299849/
https://www.ncbi.nlm.nih.gov/pubmed/35758650
http://dx.doi.org/10.7554/eLife.77780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299849/
https://www.ncbi.nlm.nih.gov/pubmed/35758650
http://dx.doi.org/10.7554/eLife.77780

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