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Hepatitis E virus infection activates NOD‐like receptor family pyrin domain‐containing 3 inflammasome antagonizing interferon response but therapeutically targetable
BACKGROUND AND AIMS: HEV infection is the most common cause of liver inflammation, but the pathogenic mechanisms remain largely unclear. We aim to explore whether HEV infection activates inflammasomes, crosstalk with antiviral interferon response, and the potential of therapeutic targeting. APPROACH...
Autores principales: | Li, Yang, Yu, Peifa, Kessler, Amy L., Shu, Jingyi, Liu, Xiaoyan, Liang, Zhaochao, Liu, Jiaye, Li, Yunlong, Li, Pengfei, Wang, Ling, Wang, Yining, Ma, Zhongren, Liu, Aixia, Bruno, Marco J., de Man, Robert A., Peppelenbosch, Maikel P., Buschow, Sonja I., Wang, Lin, Wang, Yijin, Pan, Qiuwei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299901/ https://www.ncbi.nlm.nih.gov/pubmed/34392558 http://dx.doi.org/10.1002/hep.32114 |
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