Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies

PURPOSE: Orally administered paclitaxel offers increased patient convenience while providing a method to prolong exposure without long continuous, or repeated, intravenous infusions. The oral bioavailability of paclitaxel is improved through co-administration with ritonavir and application of a suit...

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Detalles Bibliográficos
Autores principales: van Eijk, Maarten, Yu, Huixin, Sawicki, Emilia, de Weger, Vincent A., Nuijen, Bastiaan, Dorlo, Thomas P. C., Beijnen, Jos H., Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300539/
https://www.ncbi.nlm.nih.gov/pubmed/35799067
http://dx.doi.org/10.1007/s00280-022-04445-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300539/
https://www.ncbi.nlm.nih.gov/pubmed/35799067
http://dx.doi.org/10.1007/s00280-022-04445-z

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