Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends, but their mechanism of combining these distinct activities remains unclear. We addressed this by obtaining cryo-EM structures (2.6–3.9 Å) of Candida albicans Kip3 in differe...

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Detalles Bibliográficos
Autores principales: Hunter, Byron, Benoit, Matthieu P. M. H., Asenjo, Ana B., Doubleday, Caitlin, Trofimova, Daria, Frazer, Corey, Shoukat, Irsa, Sosa, Hernando, Allingham, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300613/
https://www.ncbi.nlm.nih.gov/pubmed/35859148
http://dx.doi.org/10.1038/s41467-022-31794-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300613/
https://www.ncbi.nlm.nih.gov/pubmed/35859148
http://dx.doi.org/10.1038/s41467-022-31794-3

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