Cargando…

Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape

Kinesin-8s are dual-activity motor proteins that can move processively on microtubules and depolymerize microtubule plus-ends, but their mechanism of combining these distinct activities remains unclear. We addressed this by obtaining cryo-EM structures (2.6–3.9 Å) of Candida albicans Kip3 in differe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hunter, Byron, Benoit, Matthieu P. M. H., Asenjo, Ana B., Doubleday, Caitlin, Trofimova, Daria, Frazer, Corey, Shoukat, Irsa, Sosa, Hernando, Allingham, John S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300613/ https://www.ncbi.nlm.nih.gov/pubmed/35859148 http://dx.doi.org/10.1038/s41467-022-31794-3

Ejemplares similares

Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal
por: Shoukat, Irsa, et al.
Publicado: (2019)

Tubulin protofilaments and kinesin-dependent motility
Publicado: (1992)

New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2023)

Kinesin follows the microtubule's protofilament axis
Publicado: (1993)

Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate
por: Trofimova, Daria, et al.
Publicado: (2018)

A Second Tubulin Binding Site on the Kinesin-13 Motor Head Domain Is Important during Mitosis
por: Zhang, Dong, et al.
Publicado: (2013)

A Single Protofilament Is Sufficient to Support Unidirectional Walking of Dynein and Kinesin
por: Shibata, Keitaro, et al.
Publicado: (2012)

A new model for binding of kinesin 13 to curved microtubule protofilaments
por: Mulder, Anke M., et al.
Publicado: (2009)

Mechanical splitting of microtubules into protofilament bundles by surface-bound kinesin-1
por: VanDelinder, Virginia, et al.
Publicado: (2016)

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2018)

Author Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P. M. H., et al.
Publicado: (2018)

Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments
por: McIntosh, J. Richard, et al.
Publicado: (2018)

High-Resolution Imaging of a Single Gliding Protofilament of Tubulins by HS-AFM
por: Keya, Jakia Jannat, et al.
Publicado: (2017)

Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin
Publicado: (1996)

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton
por: Pilhofer, Martin, et al.
Publicado: (2011)

Kinesin-13s form rings around microtubules
por: Tan, Dongyan, et al.
Publicado: (2006)

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2021)

Exposure of beta-tubulin regions defined by antibodies on an Arabidopsis thaliana microtubule protofilament model and in the cells
por: Blume, Yaroslav, et al.
Publicado: (2010)

Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division
por: Guan, Fenghui, et al.
Publicado: (2018)

MICROTUBULES: EVIDENCE FOR 13 PROTOFILAMENTS
por: Tilney, Lewis G., et al.
Publicado: (1973)

Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A
por: Mennella, Vito, et al.
Publicado: (2009)

Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons
por: Hammond, Jennetta W., et al.
Publicado: (2010)

Kinesin-13 regulates the quantity and quality of tubulin inside cilia
por: Vasudevan, Krishna Kumar, et al.
Publicado: (2015)

Computational Study on E-Hooks of Tubulins in the Binding Process with Kinesin
por: Xie, Yixin, et al.
Publicado: (2022)

Alterations in number of protofilaments in microtubules assembled in vitro
Publicado: (1978)

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6
por: Ranaivoson, Fanomezana Moutse, et al.
Publicado: (2023)

Tannic acid-stained microtubules with 12, 13, and 15 protofilaments
por: Burton, PR, et al.
Publicado: (1975)

Brownian dynamics simulation of protofilament relaxation during rapid freezing
por: Ulyanov, Evgeniy V., et al.
Publicado: (2021)

Kinesin-14 Pkl1 targets γ-tubulin for release from the γ-tubulin ring complex (γ-TuRC) ‬‬‬‬‬‬‬
por: Olmsted, Zachary T., et al.
Publicado: (2013)

Tubulin Acetylation Alone Does Not Affect Kinesin-1 Velocity and Run Length In Vitro
por: Walter, Wilhelm J., et al.
Publicado: (2012)

Suppression of tubulin detyrosination by parthenolide recruits the plant-specific kinesin KCH to cortical microtubules
por: Schneider, Natalie, et al.
Publicado: (2015)

Pneumococcal Pili Are Composed of Protofilaments Exposing Adhesive Clusters of Rrg A
por: Hilleringmann, Markus, et al.
Publicado: (2008)

Lattice defects in microtubules: protofilament numbers vary within individual microtubules
Publicado: (1992)

On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness
Publicado: (1986)

BtubA-BtubB Heterodimer Is an Essential Intermediate in Protofilament Assembly
por: Sontag, Christopher A., et al.
Publicado: (2009)

Correction: Brownian dynamics simulation of protofilament relaxation during rapid freezing
por: Ulyanov, Evgeniy V., et al.
Publicado: (2021)

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
por: Wang, Weiyi, et al.
Publicado: (2017)

Studies of Conformational Changes of Tubulin Induced by Interaction with Kinesin Using Atomistic Molecular Dynamics Simulations
por: Shi, Xiao-Xuan, et al.
Publicado: (2021)

A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates
por: Auer, Stefan, et al.
Publicado: (2008)

MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments
por: Al-Bassam, Jawdat, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_cs35mg2b42uvl6dm9snm8oql91