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Model-guided engineering of DNA sequences with predictable site-specific recombination rates

Site-specific recombination (SSR) is an important tool in synthetic biology, but its applications are limited by the inability to predictably tune SSR reaction rates. Facile rate manipulation could be achieved by modifying the DNA substrate sequence; however, this approach lacks rational design prin...

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Detalles Bibliográficos
Autores principales: Zhang, Qiuge, Azarin, Samira M., Sarkar, Casim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300676/
https://www.ncbi.nlm.nih.gov/pubmed/35858965
http://dx.doi.org/10.1038/s41467-022-31538-3