The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor

Glucocorticoid receptor (GR) regulates various cellular functions. Given its broad influence on metabolic activities, it has been the target of drug discovery for decades. However, how drugs induce conformational changes in GR has remained elusive. Herein, we used five GR agonists (dex, AZ938, pred,...

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Detalles Bibliográficos
Autores principales: Shi, Yuxin, Cao, Shu, Ni, Duan, Fan, Jigang, Lu, Shaoyong, Xue, Mintao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300934/
https://www.ncbi.nlm.nih.gov/pubmed/35874618
http://dx.doi.org/10.3389/fmolb.2022.933676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300934/
https://www.ncbi.nlm.nih.gov/pubmed/35874618
http://dx.doi.org/10.3389/fmolb.2022.933676

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