Cargando…

The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor

Glucocorticoid receptor (GR) regulates various cellular functions. Given its broad influence on metabolic activities, it has been the target of drug discovery for decades. However, how drugs induce conformational changes in GR has remained elusive. Herein, we used five GR agonists (dex, AZ938, pred,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Yuxin, Cao, Shu, Ni, Duan, Fan, Jigang, Lu, Shaoyong, Xue, Mintao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300934/ https://www.ncbi.nlm.nih.gov/pubmed/35874618 http://dx.doi.org/10.3389/fmolb.2022.933676

Ejemplares similares

Dynamic allostery in thrombin—a review
por: Komives, Elizabeth A.
Publicado: (2023)

Editorial: Structural and Dynamic Aspects of Protein Function and Allostery
por: Lisi, George P., et al.
Publicado: (2022)

Enzyme Kinetics by Isothermal Titration Calorimetry: Allostery, Inhibition, and Dynamics
por: Wang, Yun, et al.
Publicado: (2020)

Editorial: Understanding Protein Dynamics, Binding and Allostery for Drug Design
por: Hu, Guang, et al.
Publicado: (2021)

Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase B
por: Redzic, Jasmina S., et al.
Publicado: (2021)

Insights into the molecular mechanism of allostery in Hsp70s
por: Mayer, Matthias P., et al.
Publicado: (2015)

Structural Basis for Allostery in PLP-dependent Enzymes
por: Tran, Jenny U., et al.
Publicado: (2022)

Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect
por: He, Xuan, et al.
Publicado: (2022)

The Role of Substrate Mediated Allostery in the Catalytic Competency of the Bacterial Oligosaccharyltransferase PglB
por: Morgan, Brittany R., et al.
Publicado: (2021)

A Time-Dependent Quantum Approach to Allostery and a Comparison With Light-Harvesting in Photosynthetic Phenomenon
por: Villani, Giovanni
Publicado: (2020)

The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution
por: Crooks, James E., et al.
Publicado: (2018)

Electron Transfer Coupled to Conformational Dynamics in Cell Respiration
por: Reidelbach, Marco, et al.
Publicado: (2021)

Challenges in describing the conformation and dynamics of proteins with ambiguous behavior
por: Roca-Martinez, Joel, et al.
Publicado: (2022)

Conformational Dynamics of DNA Polymerases Revealed at the Single-Molecule Level
por: Millar, David P.
Publicado: (2022)

Effects of a plant cyclotide on conformational dynamics and destabilization of β-amyloid fibrils through molecular dynamics simulations
por: Kalmankar, Neha V., et al.
Publicado: (2022)

Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights
por: Graf, Christian, et al.
Publicado: (2014)

Kanamycin-Mediated Conformational Dynamics of Escherichia coli Outer Membrane Protein TolC
por: Pattanayak, Biraja S., et al.
Publicado: (2021)

DNA Polymerase Conformational Dynamics and the Role of Fidelity-Conferring Residues: Insights from Computational Simulations
por: Meli, Massimiliano, et al.
Publicado: (2016)

Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus Syndrome
por: Amir, Mohd., et al.
Publicado: (2019)

Molecular Dynamics to Predict Cryo-EM: Capturing Transitions and Short-Lived Conformational States of Biomolecules
por: Nierzwicki, Łukasz, et al.
Publicado: (2021)

Mutations of N1 Riboswitch Affect its Dynamics and Recognition by Neomycin Through Conformational Selection
por: Chyży, Piotr, et al.
Publicado: (2021)

Decoding the Structural Dynamics and Conformational Alternations of DNA Secondary Structures by Single-Molecule FRET Microspectroscopy
por: Bandyopadhyay, Debolina, et al.
Publicado: (2021)

Corrigendum: Molecular Dynamics to Predict Cryo-EM: Capturing Transitions and Short-Lived Conformational States of Biomolecules
por: Nierzwicki, Łukasz, et al.
Publicado: (2021)

Untargeted Metabolomic Analysis Combined With Multivariate Statistics Reveal Distinct Metabolic Changes in GPR40 Agonist-Treated Animals Related to Bile Acid Metabolism
por: Doerfler, Hannes, et al.
Publicado: (2021)

HIV-1 Envelope Conformation, Allostery, and Dynamics
por: Bennett, Ashley Lauren, et al.
Publicado: (2021)

An Unbound Proline-Rich Signaling Peptide Frequently Samples Cis Conformations in Gaussian Accelerated Molecular Dynamics Simulations
por: Alcantara, Juan, et al.
Publicado: (2021)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254–290) in Alzheimer’s Disease: A Molecular Dynamics Simulation Study
por: Alipour, Mozhgan, et al.
Publicado: (2022)

Unraveling the Influence of K280 Acetylation on the Conformational Features of Tau Core Fragment: A Molecular Dynamics Simulation Study
por: Zou, Yu, et al.
Publicado: (2021)

Explore Protein Conformational Space With Variational Autoencoder
por: Tian, Hao, et al.
Publicado: (2021)

Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
por: Laeremans, Toon, et al.
Publicado: (2022)

Phosphorylation Induced Conformational Transitions in DNA Polymerase β
por: Srivastava, Amit, et al.
Publicado: (2022)

Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review
por: Yang, Tong-Mei, et al.
Publicado: (2023)

Conformational gating, dynamics and allostery in human monoacylglycerol lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2020)

Allosterically coupled conformational dynamics in solution prepare the sterol transfer protein StarD4 to release its cargo upon interaction with target membranes
por: Xie, Hengyi, et al.
Publicado: (2023)

Agonist Binding to Chemosensory Receptors: A Systematic Bioinformatics Analysis
por: Fierro, Fabrizio, et al.
Publicado: (2017)

Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
por: Pawnikar, Shristi, et al.
Publicado: (2022)

NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules
por: Sha, Congzhou M., et al.
Publicado: (2022)

Understanding protein diffusion on force-induced stretched DNA conformation
por: Mondal, Anupam, et al.
Publicado: (2022)

Elucidation of the conformational dynamics and assembly of Argonaute–RNA complexes by distinct yet coordinated actions of the supplementary microRNA
por: Zhuang, Haiming, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j25p0kfuqs59dkc5htu4l9ujpo