Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray

This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate the development of this drug. Based on the physiology of the human upper respiratory system, the semi-PBPK mod...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofei, Zhang, Fan, Yu, Mengyang, Ding, Faming, Luo, Jinghui, Liu, Bo, Li, Yuan, Li, Zhiping, Wang, Hongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301199/
https://www.ncbi.nlm.nih.gov/pubmed/35873554
http://dx.doi.org/10.3389/fphar.2022.910629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301199/
https://www.ncbi.nlm.nih.gov/pubmed/35873554
http://dx.doi.org/10.3389/fphar.2022.910629

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