Profiling of in vivo, in vitro and reactive zorifertinib metabolites using liquid chromatography ion trap mass spectrometry

Zorifertinib (AZD-3759; ZFB) is a potent, novel, oral, small molecule used for the treatment of non-small cell lung cancer (NSCLC). ZFB is Epidermal Growth Factor Receptor (EGFR) inhibitor that is characterized by good permeability of the blood–brain barrier for (NSCLC) patients with EGFR mutations....

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Detalles Bibliográficos
Autores principales: Al-Shakliah, Nasser S., Kadi, Adnan A., Aljohar, Haya I., AlRabiah, Haitham, Attwa, Mohamed W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301632/
https://www.ncbi.nlm.nih.gov/pubmed/35919181
http://dx.doi.org/10.1039/d2ra02848d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301632/
https://www.ncbi.nlm.nih.gov/pubmed/35919181
http://dx.doi.org/10.1039/d2ra02848d

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