Structure of a 14-3-3ε:FOXO3a(pS253) Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins

[Image: see text] The transcriptional activity of Forkhead Box O3 (FOXO3a) is inactivated by AKT-mediated phosphorylation on Serine 253 (S253), which enables FOXO3a binding to 14-3-3. Phosphorylated FOXO3a binding to 14-3-3 facilitates the nuclear exclusion of FOXO3a, causing cancer cell proliferati...

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Detalles Bibliográficos
Autores principales: Mathivanan, Subashini, Chunchagatta Lakshman, Puneeth Kumar, Singh, Manvi, Giridharan, Saranya, Sathish, Keerthana, Hurakadli, Manjunath A., Bharatham, Kavitha, Kamariah, Neelagandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301721/
https://www.ncbi.nlm.nih.gov/pubmed/35874228
http://dx.doi.org/10.1021/acsomega.2c01700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301721/
https://www.ncbi.nlm.nih.gov/pubmed/35874228
http://dx.doi.org/10.1021/acsomega.2c01700

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