A single amino acid residue controls acyltransferase activity in a polyketide synthase from Toxoplasma gondii

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Type I polyketide synthases (PKSs) are multidomain, multimodule enzymes capable of producing complex polyketide metabolites. These modules contain an acyltransferase (AT) domain, which selects acyl-CoA substrates to be incorporated into the metabolite scaffold. Herein, we reveal the sequences of thr...

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Detalles Bibliográficos
Autores principales: D’Ambrosio, Hannah K., Ganley, Jack G., Keeler, Aaron M., Derbyshire, Emily R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301873/
https://www.ncbi.nlm.nih.gov/pubmed/35874921
http://dx.doi.org/10.1016/j.isci.2022.104443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301873/
https://www.ncbi.nlm.nih.gov/pubmed/35874921
http://dx.doi.org/10.1016/j.isci.2022.104443

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