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A single amino acid residue controls acyltransferase activity in a polyketide synthase from Toxoplasma gondii
Type I polyketide synthases (PKSs) are multidomain, multimodule enzymes capable of producing complex polyketide metabolites. These modules contain an acyltransferase (AT) domain, which selects acyl-CoA substrates to be incorporated into the metabolite scaffold. Herein, we reveal the sequences of thr...
Autores principales: | D’Ambrosio, Hannah K., Ganley, Jack G., Keeler, Aaron M., Derbyshire, Emily R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301873/ https://www.ncbi.nlm.nih.gov/pubmed/35874921 http://dx.doi.org/10.1016/j.isci.2022.104443 |
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