Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV

BACKGROUND: Dysfunction of CD8(+) T cells in people living with HIV-1 (PLWH) receiving anti-retroviral therapy (ART) has restricted the efficacy of dendritic cell (DC)-based immunotherapies against HIV-1. Heterogeneous immune exhaustion and metabolic states of CD8(+) T cells might differentially ass...

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Detalles Bibliográficos
Autores principales: Calvet-Mirabent, Marta, Sánchez-Cerrillo, Ildefonso, Martín-Cófreces, Noa, Martínez-Fleta, Pedro, de la Fuente, Hortensia, Tsukalov, Ilya, Delgado-Arévalo, Cristina, Calzada, María José, de los Santos, Ignacio, Sanz, Jesús, García-Fraile, Lucio, Sánchez-Madrid, Francisco, Alfranca, Arantzazu, Muñoz-Fernández, María Ángeles, Buzón, Maria J., Martín-Gayo, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301875/
https://www.ncbi.nlm.nih.gov/pubmed/35665682
http://dx.doi.org/10.1016/j.ebiom.2022.104090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301875/
https://www.ncbi.nlm.nih.gov/pubmed/35665682
http://dx.doi.org/10.1016/j.ebiom.2022.104090

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