Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation

[Image: see text] Type II diabetes is characterized by the loss of pancreatic β-cells. This loss is thought to be a consequence of membrane disruption, caused by the aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils. However, the molecular mechanisms of IAPP aggregation in the pre...

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Detalles Bibliográficos
Autores principales: Elenbaas, Barend O. W., Khemtemourian, Lucie, Killian, J. Antoinette, Sinnige, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301912/
https://www.ncbi.nlm.nih.gov/pubmed/35749314
http://dx.doi.org/10.1021/acs.biochem.2c00184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301912/
https://www.ncbi.nlm.nih.gov/pubmed/35749314
http://dx.doi.org/10.1021/acs.biochem.2c00184

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