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Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation
[Image: see text] Type II diabetes is characterized by the loss of pancreatic β-cells. This loss is thought to be a consequence of membrane disruption, caused by the aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils. However, the molecular mechanisms of IAPP aggregation in the pre...
Autores principales: | Elenbaas, Barend O. W., Khemtemourian, Lucie, Killian, J. Antoinette, Sinnige, Tessa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301912/ https://www.ncbi.nlm.nih.gov/pubmed/35749314 http://dx.doi.org/10.1021/acs.biochem.2c00184 |
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