Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity

Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes. However, the mechanism of action and overall impact on malaria transmission is still unknown. Using data from 81 adult Malians w...

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Detalles Bibliográficos
Autores principales: Chotsiri, Palang, Mahamar, Almahamoudou, Hoglund, Richard M., Koita, Fanta, Sanogo, Koualy, Diawara, Halimatou, Dicko, Alassane, Simpson, Julie A., Bousema, Teun, White, Nicholas J., Brown, Joelle M., Gosling, Roly, Chen, Ingrid, Tarning, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302630/
https://www.ncbi.nlm.nih.gov/pubmed/34905220
http://dx.doi.org/10.1002/cpt.2512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302630/
https://www.ncbi.nlm.nih.gov/pubmed/34905220
http://dx.doi.org/10.1002/cpt.2512

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