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Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model
Amino acids, the building blocks of proteins in the cells and tissues, are of fundamental importance for cell survival, maintenance, and proliferation. The liver plays a critical role in amino acid metabolism and detoxication of byproducts such as ammonia. Urea cycle disorders with hyperammonemia re...
Autores principales: | Mao, Xia, Chen, Helen, Lin, Allen Z., Kim, Sun, Burczynski, Michael E., Na, Erqian, Halasz, Gabor, Sleeman, Mark W., Murphy, Andrew J., Okamoto, Haruka, Cheng, Xiping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302672/ https://www.ncbi.nlm.nih.gov/pubmed/34988999 http://dx.doi.org/10.1002/jimd.12474 |
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