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Modulating the Coupling Efficiency of P450 BM3 by Controlling Water Diffusion through Access Tunnel Engineering

Cytochromes P450 have gained much interest for their broad substrate scope in the catalysis of oxidation reactions for pharmaceuticals, plastics, and hormones. However, achieving high coupling efficiency by the engineering of P450s is still a big challenge. The presence of extra water around the act...

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Detalles Bibliográficos
Autores principales: Meng, Shuaiqi, Ji, Yu, Liu, Luo, Davari, Mehdi D., Schwaneberg, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302676/
https://www.ncbi.nlm.nih.gov/pubmed/34936208
http://dx.doi.org/10.1002/cssc.202102434