Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers

AIMS: ALKS 7119 is a novel compound with in vitro affinity highest for the SERT, and for μ receptor, α(1A)‐adrenoceptor, α(1B)‐adrenoceptor, NMDA receptor and sigma non‐opioid intracellular receptor 1. This first‐in‐human study evaluated safety and PK/PD effects of single ascending doses (SAD) of AL...

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Detalles Bibliográficos
Autores principales: Dijkstra, Francis M., Zuiker, Rob G. J. A., Siebenga, Pieter S., Leigh‐Pemberton, Richard A., Sun, Lei, Manthis, Joan D., de Kam, Marieke L., Lin, Richard, von Moltke, Lisa L., Rezendes, David, van Gerven, Joop M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302689/
https://www.ncbi.nlm.nih.gov/pubmed/35014069
http://dx.doi.org/10.1111/bcp.15229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302689/
https://www.ncbi.nlm.nih.gov/pubmed/35014069
http://dx.doi.org/10.1111/bcp.15229

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