Cargando…

Phospholipase activity of acyloxyacyl hydrolase induces IL‐22‐producing CD1a‐autoreactive T cells in individuals with psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Recent evidence has identified Langerhans cells to have a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present lipid antigens to T cells. Phospholipase A(2) enzymes genera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Randeep, Chen, Yi‐Ling, Ng, Soo Weei, Cain, David, Etherington, Rachel, Hardman, Clare, Ogg, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Immunodeficiencies and autoimmunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302981/ https://www.ncbi.nlm.nih.gov/pubmed/34913478 http://dx.doi.org/10.1002/eji.202149485

Ejemplares similares

Human neonatal thymectomy induces altered B‐cell responses and autoreactivity
por: van den Broek, Theo, et al.
Publicado: (2017)

CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis
por: Affandi, Alsya J., et al.
Publicado: (2018)

Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice
por: Purvis, Harriet A, et al.
Publicado: (2017)

Presence, function, and regulation of IL‐17F‐expressing human CD4(+) T cells
por: Burns, Lachrissa A., et al.
Publicado: (2020)

CD4(+)CCR6(+) T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice
por: Razawy, Wida, et al.
Publicado: (2019)

Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at‐risk phase of autoantibody positive rheumatoid arthritis
por: Ramwadhdoebe, Tamara H., et al.
Publicado: (2016)

Granulocyte‐augmented chemokine production induced by type II collagen containing immune complexes is mediated via TLR4 in rheumatoid arthritis patients
por: Manivel, Vivek Anand, et al.
Publicado: (2016)

Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment
por: Grist, Jonathan J., et al.
Publicado: (2018)

The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis
por: Rijvers, Liza, et al.
Publicado: (2018)

Aberrant cell signalling in PBMCs upon IFN‐α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature
por: Davies, Richard, et al.
Publicado: (2018)

Enhancing immunity prevents virus‐induced T‐cell‐mediated immunopathology in B cell‐deficient mice
por: Straub, Tobias, et al.
Publicado: (2019)

Dysregulated CD46 shedding interferes with Th1‐contraction in systemic lupus erythematosus
por: Ellinghaus, Ursula, et al.
Publicado: (2017)

A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells
por: Haselmayer, Philipp, et al.
Publicado: (2017)

Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis
por: van Kempen, Tessa S., et al.
Publicado: (2020)

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity
por: Baars, Matthijs J.D., et al.
Publicado: (2020)

Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively
por: Vaartjes, Daniëlle, et al.
Publicado: (2020)

Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients
por: Campana, Stefania, et al.
Publicado: (2021)

Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells
por: Venkatadri, Rajkumar, et al.
Publicado: (2022)

Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency
por: Milardi, Giulia, et al.
Publicado: (2022)

Antigen receptor‐engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice
por: Pohar, Jelka, et al.
Publicado: (2022)

ACKR1 favors transcellular over paracellular T‐cell diapedesis across the blood‐brain barrier in neuroinflammation in vitro
por: Marchetti, Luca, et al.
Publicado: (2021)

Novel homozygous CD46 variant with C‐isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome
por: Schack, Vivien R., et al.
Publicado: (2022)

Toll‐like receptors control the accumulation of neutrophils in lymph nodes that expand CD4(+) T cells during experimental autoimmune encephalomyelitis
por: Shen, Ping, et al.
Publicado: (2022)

Acyloxyacyl hydrolase regulates microglia-mediated pelvic pain
por: Rahman-Enyart, Afrida, et al.
Publicado: (2022)

Practical challenges for functional validation of STAT1 gain of function genetic variants
por: Albuquerque, Adriana S, et al.
Publicado: (2023)

Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury
por: Zou, Benkun, et al.
Publicado: (2017)

Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance
por: Cheng, Xiaofang, et al.
Publicado: (2023)

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
por: Sood, Shatakshi, et al.
Publicado: (2016)

New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis
por: Navrátilová, Adéla, et al.
Publicado: (2023)

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
por: Roberts, Natalie A., et al.
Publicado: (2017)

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
por: Hodgson, Rose, et al.
Publicado: (2023)

Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis
por: Giles, Joanna L., et al.
Publicado: (2015)

Cancer immunotherapy-induced rheumatic diseases emerge as new clinical entities
por: Cappelli, Laura C, et al.
Publicado: (2016)

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
por: Nanda, Sambit K., et al.
Publicado: (2016)

Tissue-Resident Exhausted Effector Memory CD8(+) T Cells Accumulate in the Retina during Chronic Experimental Autoimmune Uveoretinitis
por: Boldison, Joanne, et al.
Publicado: (2014)

Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy
por: Leipe, Jan, et al.
Publicado: (2018)

Distinct features distinguishing IgG4-related disease from multicentric Castleman’s disease
por: Sasaki, Takanori, et al.
Publicado: (2017)

The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice
por: Jhou, Jyun‐Pei, et al.
Publicado: (2018)

Antiphospholipid syndrome: state of the art on clinical practice guidelines
por: Limper, Marteen, et al.
Publicado: (2018)

Automated evaluation of ANA under real-life conditions
por: Loock, Clemens Dario, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a6c0lpv7ase2e4kk71fcvlct4p