IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma

In this study, we synthesized a molecule GA-1MT (GM) composed of indoleamine 2,3-dioxygenase (IDO) inhibitor (1-methyl-d-tryptophan, 1MT) called NLG8189 and gallic acid (GA) and verified its therapeutic effect on B16F10 melanoma cells and an orthotopic tumor-bearing mouse model. The synthesized mole...

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Detalles Bibliográficos
Autores principales: Liu, Hongmei, Gao, Huan, Chen, Cheng, Jia, Wenyu, Xu, Delong, Jiang, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303008/
https://www.ncbi.nlm.nih.gov/pubmed/35875081
http://dx.doi.org/10.3389/fonc.2022.904229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303008/
https://www.ncbi.nlm.nih.gov/pubmed/35875081
http://dx.doi.org/10.3389/fonc.2022.904229

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