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Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine
Ribosome serves as a universal molecular machine capable of synthesis of all the proteins in a cell. Small-molecule inhibitors, such as ribosome-targeting antibiotics, can compromise the catalytic versatility of the ribosome in a context-dependent fashion, preventing transpeptidation only between pa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303264/ https://www.ncbi.nlm.nih.gov/pubmed/35766409 http://dx.doi.org/10.1093/nar/gkac548 |