Viral mediated knockdown of GATA6 in SMA iPSC‐derived astrocytes prevents motor neuron loss and microglial activation

Spinal muscular atrophy (SMA), a pediatric genetic disorder, is characterized by the profound loss of spinal cord motor neurons and subsequent muscle atrophy and death. Although the mechanisms underlying motor neuron loss are not entirely clear, data from our work and others support the idea that gl...

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Detalles Bibliográficos
Autores principales: Allison, Reilly L., Welby, Emily, Khayrullina, Guzal, Burnett, Barrington G., Ebert, Allison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303278/
https://www.ncbi.nlm.nih.gov/pubmed/35088910
http://dx.doi.org/10.1002/glia.24153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303278/
https://www.ncbi.nlm.nih.gov/pubmed/35088910
http://dx.doi.org/10.1002/glia.24153

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