Membrane-dependent relief of translation elongation arrest on pseudouridine- and N(1)-methyl-pseudouridine-modified mRNAs

Expression of therapeutically important proteins has benefited dramatically from the advent of chemically modified mRNAs that feature decreased lability and immunogenicity. This had a momentous effect on the rapid development of COVID-19 mRNA vaccines. Incorporation of the naturally occurring pseudo...

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Detalles Bibliográficos
Autores principales: Svitkin, Yuri V, Gingras, Anne-Claude, Sonenberg, Nahum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303281/
https://www.ncbi.nlm.nih.gov/pubmed/34933339
http://dx.doi.org/10.1093/nar/gkab1241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303281/
https://www.ncbi.nlm.nih.gov/pubmed/34933339
http://dx.doi.org/10.1093/nar/gkab1241

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