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Membrane-dependent relief of translation elongation arrest on pseudouridine- and N(1)-methyl-pseudouridine-modified mRNAs
Expression of therapeutically important proteins has benefited dramatically from the advent of chemically modified mRNAs that feature decreased lability and immunogenicity. This had a momentous effect on the rapid development of COVID-19 mRNA vaccines. Incorporation of the naturally occurring pseudo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303281/ https://www.ncbi.nlm.nih.gov/pubmed/34933339 http://dx.doi.org/10.1093/nar/gkab1241 |