Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases

Polyglutamine (polyQ) diseases are a type of inherited neurodegenerative disorders caused by cytosine–adenine–guanine (CAG) trinucleotide expansion within the coding region of the disease-associated genes. We previously demonstrated that a pathogenic interaction between expanded CAG RNA and the nucl...

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Detalles Bibliográficos
Autores principales: An, Ying, Chen, Zhefan S, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303306/
https://www.ncbi.nlm.nih.gov/pubmed/35776134
http://dx.doi.org/10.1093/nar/gkac532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303306/
https://www.ncbi.nlm.nih.gov/pubmed/35776134
http://dx.doi.org/10.1093/nar/gkac532

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