Cargando…

Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases

Polyglutamine (polyQ) diseases are a type of inherited neurodegenerative disorders caused by cytosine–adenine–guanine (CAG) trinucleotide expansion within the coding region of the disease-associated genes. We previously demonstrated that a pathogenic interaction between expanded CAG RNA and the nucl...

Descripción completa

Detalles Bibliográficos
Autores principales:	An, Ying, Chen, Zhefan S, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303306/ https://www.ncbi.nlm.nih.gov/pubmed/35776134 http://dx.doi.org/10.1093/nar/gkac532

Ejemplares similares

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases
por: Kiliszek, Agnieszka, et al.
Publicado: (2010)

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases
por: Zhang, Qian, et al.
Publicado: (2018)

CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration
por: Peng, Shaohong, et al.
Publicado: (2021)

E-motif formed by extrahelical cytosine bases in DNA homoduplexes of trinucleotide and hexanucleotide repeats
por: Pan, Feng, et al.
Publicado: (2018)

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks
por: Schaefer, Martin H., et al.
Publicado: (2012)

Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats
por: Malgowska, Magdalena, et al.
Publicado: (2014)

Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats
por: Mukherjee, Sanjukta, et al.
Publicado: (2019)

Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich’s ataxia: DNA triplexes and RNA/DNA hybrids
por: Zhang, Jiahui, et al.
Publicado: (2020)

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
por: Zhang, Nan, et al.
Publicado: (2021)

Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes
por: Gudanis, Dorota, et al.
Publicado: (2016)

Length-dependent energetics of (CTG)(n) and (CAG)(n) trinucleotide repeats
por: Amrane, Samir, et al.
Publicado: (2005)

Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
por: Liu, Guoqi, et al.
Publicado: (2012)

Genome Wide Screening of CAG Trinucleotide Repeat Lengths in Breast Cancer
por: Jarjanazi, Hamdi, et al.
Publicado: (2006)

Dynamics of strand slippage in DNA hairpins formed by CAG repeats: roles of sequence parity and trinucleotide interrupts
por: Xu, Pengning, et al.
Publicado: (2020)

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
Publicado: (2019)

Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
por: Richard, Guy-Franck, et al.
Publicado: (2014)

Slipped-CAG DNA binding small molecule induces trinucleotide repeat contractions in vivo
por: Nakamori, Masayuki, et al.
Publicado: (2020)

Structural insights into CUG repeats containing the ‘stretched U–U wobble’: implications for myotonic dystrophy
por: Kiliszek, Agnieszka, et al.
Publicado: (2009)

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
por: Xu, Meng, et al.
Publicado: (2014)

CAG-encoded polyglutamine length polymorphism in the human genome
por: Butland, Stefanie L, et al.
Publicado: (2007)

Studies on Copper and Aβ(1-16)-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence
por: Govindaraju, M., et al.
Publicado: (2017)

Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs
por: Xu, Jun, et al.
Publicado: (2021)

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats
por: Reddy, Kaalak, et al.
Publicado: (2011)

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function
por: Vijayvargia, Ravi, et al.
Publicado: (2016)

Structural insights into the cooperative binding of SeqA to a tandem GATC repeat
por: Chung, Yu Seon, et al.
Publicado: (2009)

Development of Fluorescent Turn-On Probes for CAG-RNA Repeats
por: Lau, Matthew Ho Yan, et al.
Publicado: (2022)

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice
por: Møllersen, Linda, et al.
Publicado: (2012)

A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT)
por: De Luca, Alessandro, et al.
Publicado: (2021)

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila
por: Zhang, Qian, et al.
Publicado: (2016)

Diagrammatic approaches to RNA structures with trinucleotide repeats
por: Mak, Chi H., et al.
Publicado: (2021)

The origin of genetic instability in CCTG repeats
por: Lam, Sik Lok, et al.
Publicado: (2011)

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
por: Kandola, Tej, et al.
Publicado: (2023)

Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease
por: Chu, Yongjun, et al.
Publicado: (2020)

Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome
por: Kiliszek, Agnieszka, et al.
Publicado: (2011)

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases
por: Zhang, Qian, et al.
Publicado: (2017)

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
por: Dalhus, Bjørn, et al.
Publicado: (2007)

Polyglutamine Repeats in Viruses
por: Schein, Catherine H.
Publicado: (2018)

Trinucleotide repeats in human genome and exome
por: Kozlowski, Piotr, et al.
Publicado: (2010)

Trinucleotide repeats: triggers for genomic disorders?
por: Kozlowski, Piotr, et al.
Publicado: (2010)

Trinucleotide Repeats: A Structural Perspective
por: Almeida, Bruno, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_amlhpsgdjss53prpq1ablrt3ua