Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors

Herein we report the structure‐activity and structure‐physicochemical property relationships of a series of class I selective ortho‐aminoanilides targeting the “foot‐pocket” in HDAC1&2. To balance the structural benefits and the physicochemical disadvantages of these substances, we started with...

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Detalles Bibliográficos
Autores principales: Schäker‐Hübner, Linda, Haschemi, Reza, Büch, Thomas, Kraft, Fabian B., Brumme, Birke, Schöler, Andrea, Jenke, Robert, Meiler, Jens, Aigner, Achim, Bendas, Gerd, Hansen, Finn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303312/
https://www.ncbi.nlm.nih.gov/pubmed/35073610
http://dx.doi.org/10.1002/cmdc.202100755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303312/
https://www.ncbi.nlm.nih.gov/pubmed/35073610
http://dx.doi.org/10.1002/cmdc.202100755

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