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Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides
Currently, gapmer antisense oligonucleotide (ASO) therapeutics are under clinical development for the treatment of various diseases, including previously intractable human disorders; however, they have the potential to induce hepatotoxicity. Although several groups have reported the reduced hepatoto...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303313/ https://www.ncbi.nlm.nih.gov/pubmed/35801870 http://dx.doi.org/10.1093/nar/gkac562 |